HANDINI, Ellyana Nur (2021) Formulasi Gel Ekstrak Metanol Terfurifikasi Tanaman Api-Api (Avicennia Marina) dengan Gelling Agent CMC. Skripsi thesis, Universitas Jenderal Soedirman.

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Abstract

Api-api (Avicennia marina) leaves contain secondary metabolites such as flavonoid, tannin, saponin, terpenoid, and alkaloid play a role in the healing process of burns. This study was aimed to determine the effect of variations of gelling agent CMC concentration on physical properties and the stability of Api-api leaves methanol extract purified gel. Methods: This study is experimental researches includes extraction and purification of Api-api leaves, formulation of gel preparations, and evaluation of physical properties and gel stability. The gels were prepared with a variation of CMC concentration of 2%, 3%, 4%, and 5%. Each gel was evaluated for physical properties and the stability for 28 days. The results of the physical evaluation and gel preparations were analyzed using Graphpad Prism. Results: Variations in CMC concentration in Api-api leaves purified methanol extract gel can increase viscosity and adhesion, decrease dispersion, and stable in freeze-thaw stability. This is due to the presence of propylene glycol as a humectant which easily binds water from the air and increases the volume of water in the gel. Conclusion: Api-api leaves purified methanol extract gel that meets the requirement is Formula IV with 5% CMC concentration. Keywords: Avicennia marina, Gelling agent, CMC, Gel

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