Wisanggeni, Pramudya (2024) The Ability of Plasmodium falciparum Infection In Erythrocytes Treated With Chlorella vulgaris Extract In Vitro. Skripsi thesis, Universitas Jenderal Soedirman.
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Abstract
Plasmodium falciparum is the deadliest cause of malaria, which affects human erythrocytes and is transmitted by infected female Anopheles spp. Mosquitoes. The infection of P. falciparum also exhibits unlimited antigenic variations on infected erythrocytes, leading to increased drug resistance in malaria parasites. Chlorella vulgaris is a microalga inhabiting freshwater and marine environments. C. vulgaris contains various bioactive compounds needs to be assessed for its activity against P. falciparum infection. The objective of this study is to determine the infectivity of P. falciparum in human erythrocytes influenced by various doses of C. vulgaris extract in vitro, and to identify the most effective dose of C. vulgaris extract in inhibiting P. falciparum infectivity This research will be conducted experimentally using a Completely Randomized Design (CRD) and analyzed using analysis of variance (ANOVA) with further duncan test.The treatments consist of various doses of C. vulgaris extract, which are 0 μg/ml (control), 25 μg/ml, 50 μg/ml, 100 μg/ml, and 200 μg/ml, each with three replications. The observed parameters include the number of erythrocytes infected by P. falciparum and the percentage inhibition of P. falciparum in the in vitro culture medium following the administration of various doses of C. vulgaris extract. The results showed that the dose of the extract had a significant effect on the degree of parasitemia (p < 0.05). The further test using Duncan show results that is most effective in inhibiting the infectivity of P. falciparum and decreasing in parasitemia degree are 50 μg /mL. This believed that C. vulgaris compound such as phycocyanin and karotenoid able to inhibit parasitemia activity in the erythrocytes. Keyword: Ressistance, P. falciparum, C. vulgaris, in vitro, Inhibiting ability
| Item Type: | Thesis (Skripsi) |
|---|---|
| Nomor Inventaris: | B24025 |
| Uncontrolled Keywords: | Ressistance, P. falciparum, C. vulgaris, in vitro, Inhibiting ability. |
| Subjects: | D > D328 Drugs Homeopathy Medical botany |
| Divisions: | Fakultas Biologi > S1 Biologi |
| Depositing User: | Mr Pramudya Wisanggeni |
| Date Deposited: | 21 Feb 2024 08:04 |
| Last Modified: | 21 Feb 2024 08:04 |
| URI: | http://repository.unsoed.ac.id/id/eprint/26115 |
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