SARI, Setia Permata (2025) The Effect of Mango Peel (Mangifera Indica L) Brewing On Fasting Blood Sugar Levels In Wistar Rats (Rattus Norvegicus) Induced By Alloxan. Skripsi thesis, Universitas Jenderal Soedirman.

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Abstract

Diabetes is a disease caused by metabolic disorders in the pancreas, resulting in insufficient insulin production. This condition causes an increase in blood sugar levels in the blood, known as hyperglycemia and this condition affects fasting blood sugar levels. This study aims to determine the effect of mango peel (Mangifera Indica L) brewing on fasting blood sugar levels in alloxan induced Wistar rats (Rattus Norvegicus). This study used a true experimental prettest and posttest method with control group design. The sample amounted to 24 rats, which were divided into 6 treatment groups. The treatment group consisted of: healthy control group (A), negative control group (B), arumanis mango peel brew 100mg/200gBW (C), manalagi mango peel brew 100mg/200gBW (D) , indramayu mango peel brew 100mg/200gBW (E) and glibenclamide group dose 0,09mg/200gBW (F). fasting blood sugar measurements were measured using a strip glucometer and pretest posttest data were analyzed using the One Way ANOVA test and continued with the Duncan post hoc test. The results showed that the administration of mango peel was effective in reducing fasting blood sugar levels. The decrease in fasting blood sugar levels produced by each type of mango peel with the same dose as follows: Arumanis mango peel 120.50 ± 7,594 mg/dL, Manalagi mango peel 140.75 ± 5,058 mg/dL and Indramayu mango peel 165.75 ± 2,500 mg/dL. The administration of Indramayu mango peel brew at a dose of 100 mg/200gBB proved to be the most effective in reducing fasting blood sugar levels.

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